Tyramine and Depression

Question:

I am looking for a relation between Tyramine and Depression. I am not on any medication. I am feeling fine as long as I avoid food containing tyramine. Tyramine containing food causes a severe depression and sometimes migraine. Any answer?

Response:

Hi Susa, Welcme to the ng. I did not find a connection between Tyramine and Depression. > I am looking for a relation between Tyramine and Depression. I am not > on any medication. I am feeling fine as long as I avoid food > containing tyramine. > Tyramine containing food causes a severe depression and sometimes > migraine. > Any answer?

TYRAMINE Tyramine is a product of tyrosine decarboxylation that occurs during pickling, fermenting, aging and the curing and smoking of foods. Tyramine causes norepinephrine and epinephrine to be released from nerve endings. People taking monoamine oxidase inhibitors are particularly at risk. IMPLICATIONS: *       CLUSTER HEADACHES *       MIGRAINE HEADACHES *       OTHER VASCULAR HEADACHES *       UNUSUAL PRESSURE AND/OR HEART BEAT SENSATIONS *       APPREHENSION Peace, Lynda

Response:

> I am looking for a relation between Tyramine and Depression. I am not > on any medication. I am feeling fine as long as I avoid food > containing tyramine. > Tyramine containing food causes a severe depression and sometimes > migraine. > Any answer?

This trait was researched as a possible marker for unipolar depression about a decade ago, but there was found to be too much variability amongst subjects for this to become a useful test strategy. IMHO, it might indicate a genetic weakness in your MAO enzymes, or the liver detox systems. Here’s an abstract: Biol Psychiatry 1995 Dec 1;38(11):730-6 Tyramine conjugation deficit in migraine, tension-type headache, and depression. Merikangas KR, Stevens DE, Merikangas JR, Katz CB, Glover V, Cooper T, Sandler M. Department of Psychiatry and Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. This study was designed to investigate tyramine sulfate conjugation in patients with migraine or tension-type headache, as defined by the newly introduced International Headache Society (IHS) criteria and to examine whether this relationship is mediated by major depression. A total of 62 subjects completed the study: 38 with migraine (22 with aura and 16 without aura), 12 with tension-type headache, and 12 controls. Patients with migraine had significantly lower urinary tyramine sulfate excretion following oral tyramine challenge than normal control. Tension-type headache was also associated with low tyramine conjugation, but only when comorbid with depression. Although mean tyramine sulfate output was lower among subjects with major depression within each of the subtypes of headache, no significant main effect emerged for depression or major subtype thereof. The lower tyramine sulfate excretion values among patients with both migraine and depression compared to those of migraine alone or depression alone in our data and those of others suggests that comorbid migraine with depression may represent a more severe form of migraine than migraine alone. The findings underscore the importance of comorbidity in clinical and epidemiological studies of migraine. Regards, Larry

Response:

Related Posts